Sobhan's research is focused on an MHC class I-like molecule, CD1c, and its recognition by αβ and γδ T cells. He is using immunological, crystallographic and biochemical techniques to understand the molecular basis of lipid antigen presentation and its interaction with T cell receptors. Sobhan enjoys cricket, soccer, and trying out new cooking recipes.
Cara is studying the antigen diversity of the MHC class I-like molecule, MR1, and the molecular mechanisms of antigen discrimination by MR1-restricted TCRs. She is also particularly interested in how this discrimination leads to recognition of infection by specific microbial pathogens by these MR1-restricted T cells. Cara is a very passionate Duke basketball fan.
Caitlin is examining the role of CD1d-reactive gamma delta (γδ) T cells in human diseases. She is specifically interested in the prevalence, in vivo significance, and functional characteristics of these cells in colorectal tumors. She is also studying the stucture and function of γδ T cell receptors in sharks. In her free time Caitlin enjoys reading, playing banjo and volunteering as a tour guide at the Robie House with the Frank Lloyd Wright Trust.
Caitlin is an American Cancer Society Postdoctoral Fellow.
Peter, in a partnership between Prof. Adams and Prof. Ka Yee Lee, is investigating α-Synuclein, an intrinsically disordered protein linked to Parkinson’s. He is focused on using biophysical and biochemical methods to characterize α-Synuclein binding and conformation. Peter enjoys cooking different cuisines and is a glutton for punishment, rooting for the California Golden Bears in football and basketball.
Peter is a Kadanoff-Rice Postdoctoral Fellow.
Kristof is working on understanding how unique NK cell receptors function to recognize unique ligands and MHC-related molecules during homeostasis and in various disease-state pathologies such as cancer. He is working to understand these interactions through biochemical, structural, and cellular-based approaches. When Kristof is not in lab, he enjoys practicing Brazilian jiujitsu, playing piano, and spending time with his wife and dog.
Kristof is a Cancer Research Institute Postdoctoral Fellow.
In her doctoral thesis project, Marta combines a range of biochemical, genetic and cellular techniques to study γδ T cells response to human diseases. As a member of UCBA and Women in STEM she encourages and is being encouraged to pursue a career in science. Outside the lab you can find her running and biking on the Lakefront Trail. If you mention that you play chess, she will likely challenge you with a game.
Ryan is interested in the biophysical mechanisms of self-antigen recognition by regulatory T (Treg) cells. He is most interested in how these properties influence Treg development and suppression. When he’s not in lab, Ryan enjoys running triathlons very slowly, learning piano, reading, and spending as much time outside as possible.
Chris aims to elucidate the details of the dynamics of conformational changes of proteins involved in Vγ9Vδ2 T cell activation. He will primarily use biophysical techniques like atomic force microscopy and molecular dynamics simulations. When he's not in the lab, Chris likes to be out watching or playing football, basketball, and hockey.
In collaboration with the Lynch Lab, Philipp is interested in the role of MHC molecules in resolving the immunological paradox of pregnancy in humans and non-human primates. When not in lab, he’s likely volunteering at the Museum of Science and Industry, staying fit, having a beer, and/or playing guitar (all at the same time).
Cole is interested in the mechanism of antigen presentation by the MHC-like molecule MR1 and the structural features governing antigen discrimination by MR1-restricted TCRs. In her free time, you can find her attending musicals, reading, and doing yoga.
Cole is supported by the Molecular and Cellular Biology T32 training grant.
Sophie is a biochemist with a strong interest in protein structural biology. She is currently focusing on the structure of certain natural killer cell receptors and their interactions with various ligands. Outside of the lab, Sophie enjoys singing and performing, running, scouring cooking blogs for new recipes to make, and attempting to watch every British mystery TV show ever produced.
Natalie studies the activation of Vγ9Vδ2 T cells, with a focus on the interaction between phosphoantigens and BTN3A1 membrane receptors. At UChicago she plans to major in both Biochemistry and Chemistry. Outside of lab and coursework she enjoys singing, hiking, and getting really excited about other people’s dogs.
Natalie is a Beckman Scholar.
Sam is a Biological Sciences major studying the role of antigen recognition in the recruitment and activation of T regulatory cells. Outside of lab you may find him reading scifi, listening to psychedelic rock LPs, brewing tea, or cooking.
Daniel studies the interactions between NK cell receptors and ligands, with a specific interest in the mechanisms differentiating activating vs. inhibitory signals. Outside of lab, he is involved with UCEMS and UChicago Science Olympiad. In his free time, you may find him practicing calligraphy or struggling to take care of his pet succulent, Edə. He also enjoys stationery, but he's most passionate about fountain pens, inks, and paper. Ask him about pens!
Tala is a Biochemistry major studying the nature of the antigens presented by non-classical MHC molecules. When not studying or working, you can find Tala reading, listening to music, or watching the latest crime shows.
John Leonard, PhD (2014-2018)
Adrienne Luoma, PhD (2014-2016)
Andrew Sandstrom, PhD (2014)
Jacinto Lopez-Sagaseta, PhD (2009-2014)
Aparna Palakodeti, PhD (2009-2011)
Kajal Chourdhary, PhD (2007-2008)
Ramya Parameswaran (2018), MSTP, University of Chicago
May Gu, PhD (2018), Postdoc in Handel lab, UC San Diego
Charlie Dulburger, PhD (2017), Postdoc in Rubin lab, Harvard
James Crooks, PhD (2015), Senior Software Engineer, Litmus Health
Adrienne Luoma, PhD (2014), Postdoc in Wucherpfennig lab, Harvard
Andrew Sandstrom, PhD (2014), Postdoc in Vance Lab, UC Berkeley
Greg Tietjen, PhD (2013), Assistant Professor, Surgery: Transplant & Immunology, Yale
Caitlyn Yeykal, PhD (2012), Global Project Management at Merck
Louise Scharf, PhD (2010), PostDoc in Bjorkman Lab, Caltech
Zuzanna Kotkowska (2017)
Wioletta Nawrocka (2015), pursuing PhD at University of Chicago
Agata Oruba (2008), pursuing PhD at Max Plank Institute, Frankfurt Germany
Filip Golebiowski (2007), pursuing PhD at University of Krakow, Poland
Mary Coomes (2015-2017), medical assistant at Planned Parenthood
Ady Steinbach (2014-2017), pursuing PhD at UCSF
Victor Liu (2012-2014), pursuing Medical degree at University of Texas Houston
Carissa Lim (2013-2015)
Joel Siegel (2012-2013)
Irvin Ho (2011-2012)
Jenifer Kung (2010-2012), pursuing PhD at UCSF
Lakshmi Sundaresan (2010-2012)
Allison Kazen (2006-2010), Undergraduate Honors
Steve Mudroch (2009-2010)
Allison Roberts (2006-2008), Undergraduate Honors, pursuing PhD in Barton Lab at UC Berkely
Wesley Jun (2006-2007), pursuing PhD in Lengyel Lab, University of Chicago
Undergraduate Research Visiting Summer Students:
Leah Sibener (Summer 2010)
Sneha Shah (Summer 2009)
Heather Lavezzi (Summer 2008)
Valentina Dimitrova (Summer 2008)
John Haughner (Summer 2007)
Hoa B Nguyen (Summer 2006)
University of Chicago Post-Baccalaureate Research Education Program (PREP):
Natassia Buckridge (2015)
Gabrielle McRae (2011)
Department of Biochemistry and Molecular Biology
929 E. 57th Street
Chicago, IL 60637
Lab Phone: 773-834-0660
Office Phone: 773-834-9816
Department Fax: 773-702-0439