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1. Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ. Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.  J Immunol. 2016 Feb 15;196(4):1933-42. doi: 10.4049/jimmunol.1502202. Epub 2016 Jan 11. PubMed PMID: 26755823; PubMed Central PMCID: PMC4744554. 

2. Castro CD, Luoma AM, Adams EJ.  Coevolution of T-cell receptors with MHC and non-MHC ligands. Immunological reviews. 2015; 267(1):30-55. NIHMSID: NIHMS702516  PubMed [journal] PMID: 26284470, PMCID: PMC4544829

3. Adams EJ, Gu S, Luoma AM.  Human gamma delta T cells: Evolution and ligand recognition.. Cellular immunology. 2015; 296(1):31-40. NIHMSID: NIHMS688169 PubMed [journal] PMID: 25991474, PMCID: PMC4466157

4. Gu S, Nawrocka W, Adams EJ.  Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells.. Front Immunol. 2015 Jan 22;5:688. doi: 10.3389/fimmu.2014.00688.

5. Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ. .  Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.   Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43):E4648-57. PubMed [journal] PMID: 25298532, PMCID: PMC4217448

6. Luoma AM, Castro CD, Adams EJ.  γδ T cell surveillance via CD1 molecules.  Trends in immunology. 2014; 35(12):613-621. NIHMSID: NIHMS633329 PubMed [journal] PMID: 25283967, PMCID: PMC4383740

7. Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Gesnel MC, Breathnach R, Bonneville M, Scotet E, Adams EJ. The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.  Immunity. 2014; 40(4):490-500. NIHMSID: NIHMS578760 PubMed [journal] PMID: 24703779, PMCID: PMC4028361

8. Tietjen GT, Gong Z, Chen CH, Vargas E, Crooks JE, Cao KD, Heffern CT, Henderson JM, Meron M, Lin B, Roux B, Schlossman ML, Steck TL, Lee KY, Adams EJ.  Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(15):E1463-72. PubMed [journal] PMID:
24706780, PMCID: PMC3992656

9. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ.  Crystal  structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.  Immunity. 2013; 39(6):1032-42. NIHMSID: NIHMS538417 PubMed [journal] PMID: 24239091, PMCID: PMC3875342

10. López-Sagaseta J, Dulberger CL, McFedries A, Cushman M, Saghatelian A, Adams EJ.   MAIT recognition of a stimulatory bacterial antigen bound to MR1.   Journal of immunology (Baltimore, Md. : 1950). 2013; 191(10):5268-77. NIHMSID: NIHMS523382 PubMed [journal] PMID: 24108697, PMCID: PMC3819123

11. López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(19):E1771-8. PubMed [journal] PMID: 23613577, PMCID: PMC3651419

12. Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E,  Bonneville M, Adams EJ. The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. The Journal of biological chemistry. 2012; 287(39):32780-90. PubMed [journal] PMID: 22846996, PMCID: PMC3463320

13. Adams EJ, Luoma AM. The yin and yang of CD1d recognition.  Nat Immunol. 2012 Sep;13(9):814-5. doi: 10.1038/ni.2401. PubMed PMID: 22910387. 

14. López-Sagaseta J, Sibener LV, Kung JE, Gumperz J, Adams EJ.   Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.   The EMBO journal. 2012; 31(8):2047-59. PubMed [journal] PMID: 22395072, PMCID: PMC3343337

15. Sandstrom A, Scharf L, McRae G, Hawk AJ, Meredith SC, Adams EJ.   γδ T cell  receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion. The Journal of biological chemistry. 2012; 287(8):6035-43. PubMed [journal] PMID: 22215668, PMCID: PMC3285370

16. López-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ.   The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor.   PLoS Biol. 2012;10(10):e1001412. doi: 10.1371/journal.pbio.1001412. Epub 2012 Oct 23. PubMed PMID: 23109910; PubMed Central PMCID: PMC3479090. 

17. Adams EJ, Luoma AM. The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.. Annu Rev Immunol. 2013;31:529-61. doi: 10.1146/annurev-immunol-032712-095912. Epub 2013 Jan 7. Review. PubMed PMID: 23298204.

18. Kazen AR, Adams EJ. Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.  Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E332-40. doi: 10.1073/pnas.1105105108. Epub 2011 Jul 5. PubMed PMID: 21730193; PubMed Central PMCID: PMC3141992. 

19. Adams EJ, López-Sagaseta J. The immutable recognition of CD1d. Immunity. 2011 Mar 25;34(3):281-3. doi: 10.1016/j.immuni.2011.03.006. PubMed PMID: 21435579. 

20. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ.  The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010 Dec 14;33(6):853-62. doi: 10.1016/j.immuni.2010.11.026. PubMed PMID: 21167756; PubMed Central PMCID: PMC3010391. 

ADDRESS

Department of Biochemistry and Molecular Biology
929 E. 57th Street 
GCIS W229
Chicago, IL 60637 

CONTACT

Email: ejadams@uchicago.edu
Lab Phone: 773-834-0660
Office Phone: 773-834-9816
Department Fax: 773-702-0439